OsteoFlo® NanoPutty® Key Features

Nano-Surface Technology

Stimulates cellular activity and osteointegration through quadphasic resorption.

Quadphasic Particle Resorption Profile

Each quadphasic particle is composed of HA, Bioactive Glass, b-TCP, and a-TCP for optimizing sustainable bone growth.

Increased Effectiveness

GLP studies have demonstrated increased effectiveness over market leading bioglass putty.

Highly Formable and Moldable

Flowable putty great for filling tight space/voids. No sticky residue and does not require mixing, additives, or prior treatment.

Surface Technology

Magnification of quadphasic particle at 100,000X shows nano-surface structures less than 100 nm

OsteoFlo NanoPutty has a large surface area that contains nano and submicron structures similar to bone

  • True nano-structures must be less than 100 nanometers
  • Nano-surface area increases surface area and optimizes cell recognition. Nanotopography is considered to have a great effect on proliferation, differentiation and adhesion of osteoblastic cells2.

Resorption Matters

Quadphasic Synthetic Bone Graft

OsteoFlo NanoPutty has been intelligently engineered with a novel formulation of materials proven to grow bone. These 4 materials have been combined strategically to have a synergistic effect on bone growth at different time points. Bioglass, alpha tricalcium phosphate (α-TCP), beta-tricalcium phosphate (β-TCP) and hydroxyapatite(HA) are manufactured in one particle for homogenous distribution throughout the bone graft.

*In a GLP preclinical model comparing OsteoFlo NanoPutty to bioglass predicate at 4,8 and 12 weeks, OsteoFlo NanoPutty showed greater bone growth at all time points 1

Histological Review of OsteoFlo NanoPutty Compared to Bioglass Predicate at 4, 8, and 12 Weeks Post-Op (assessing 55 animals)

4 Weeks

2x Bone Growth compared to bioglass predicate¹

8 Weeks

Sustained and higher bone growth rate when compared to bioglass predicate¹

12 Weeks

No resorption pockets and continued bone growth at a higher rate when compared to bioglass predicate¹

Excellent Handling Characteristics

Flowable NanoPutty is ideal to fill tight spaces, resist migration and won’t washout during irrigation.

INDICATIONS FOR USE/INTENDED USE

OsteoFlo is an osteoconductive synthetic bone graft indicated for use in orthopedic surgical sites to fill bony voids and gaps and to aid healing/ promote bone growth post-operation.

The graft is composed of HA, a-TCP, B-TCP, and bioactive glass. It is available in various graft quantities packaged in a syringe or a graft tube. The device has a composition that is moldable/flowable to allow it to be packed into bone voids with no mixing required.

All components are provided to the hospital sterilized and single use only.