Bone grafting has advanced significantly over the years, with newer technologies designed to improve outcomes for patients and provide surgeons with more reliable tools. One of the leading innovations in this field is OsteoFlo NanoPutty, a synthetic bone graft that combines advanced material science with ease of use. Designed to address complex clinical needs, this graft is highly effective for orthopedic surgical sites where voids and gaps must be filled to promote healing and sustainable bone growth. According to Healio, the most common lumbar diagnoses were spinal stenosis at 59.7%, highlighting the importance of effective grafting solutions in spinal procedures. OsteoFlo NanoPutty has been engineered to support such cases with superior technology and clinical performance.
Advanced Nano-Surface Technology
What makes OsteoFlo NanoPutty unique is its nano-surface technology. Under magnification at 100,000X, each quadphasic particle reveals nano-structures less than 100 nanometers, closely mimicking natural bone. These nano and submicron structures increase the surface area of the graft and optimize cell recognition. This nanotopography has been shown to significantly impact the proliferation, differentiation, and adhesion of osteoblastic cells, leading to improved osteointegration and bone regeneration. In simple terms, the design helps the body recognize and grow new bone more efficiently.
Quadphasic Resorption for Sustainable Growth
OsteoFlo NanoPutty is composed of four proven materials—hydroxyapatite (HA), bioactive glass, beta-tricalcium phosphate, and alpha-tricalcium phosphate. These are strategically combined within each particle to deliver a quadphasic resorption profile. This means that each material dissolves at different rates, supporting bone growth at various stages of the healing process. The result is a graft that doesn’t just work in the short term but continues to promote new bone formation over weeks and months, avoiding resorption pockets and ensuring steady progress.
Proven Effectiveness and Clinical Advantages
Preclinical GLP studies have shown OsteoFlo NanoPutty outperforms market-leading bioglass putty. Comparative studies across 4, 8, and 12 weeks demonstrated greater bone growth at every stage. At four weeks, OsteoFlo showed twice the bone growth compared to bioglass, and by 12 weeks, it maintained a higher growth rate with no resorption pockets. These findings reinforce the strength of its quadphasic design. Additionally, its excellent handling characteristics make it easy for surgeons to use. The putty is moldable, flowable, and can be packed into tight spaces without sticking or requiring mixing. It resists migration and won’t wash out during irrigation, providing confidence during procedures.
OsteoFlo NanoPutty represents a major step forward in synthetic bone graft technology, combining nano-surface engineering, quadphasic resorption, and proven clinical effectiveness. At SurGenTec, we are proud to provide innovative solutions like OsteoFlo that enhance surgeon performance and patient outcomes in orthopedic and spinal procedures.