Stimulates cellular activity and osteointegration through quadphasic resorption.
OsteoFlo® NanoPutty® Key Features
Nano-Surface Technology
Quadphasic Particle Resorption Profile
Each quadphasic particle is composed of HA, Bioactive Glass, b-TCP, and a-TCP for optimizing sustainable bone growth.
Increased Effectiveness
GLP studies have demonstrated increased effectiveness over market leading bioglass putty.
Highly Formable and Moldable
Flowable putty great for filling tight space/voids. No sticky residue and does not require mixing, additives, or prior treatment.
Surface Technology
Magnification of quadphasic particle at 100,000X shows nano-surface structures less than 100 nm
OsteoFlo NanoPutty has a large surface area that contains nano and submicron structures similar to bone
- True nano-structures must be less than 100 nanometers
- Nano-surface area increases surface area and optimizes cell recognition. Nanotopography is considered to have a great effect on proliferation, differentiation and adhesion of osteoblastic cells2.
Resorption Matters
Quadphasic Synthetic Bone Graft
OsteoFlo NanoPutty has been intelligently engineered with a novel formulation of materials proven to grow bone. These 4 materials have been combined strategically to have a synergistic effect on bone growth at different time points. Bioglass, alpha tricalcium phosphate (α-TCP), beta-tricalcium phosphate (β-TCP) and hydroxyapatite(HA) are manufactured in one particle for homogenous distribution throughout the bone graft.
*In a GLP preclinical model comparing OsteoFlo NanoPutty to bioglass predicate at 4,8 and 12 weeks, OsteoFlo NanoPutty showed greater bone growth at all time points 1
Histological Review of OsteoFlo NanoPutty Compared to Bioglass Predicate at 4, 8, and 12 Weeks Post-Op (assessing 55 animals)
4 Weeks
2x Bone Growth compared to bioglass predicate¹
8 Weeks
Sustained and higher bone growth rate when compared to bioglass predicate¹
12 Weeks
No resorption pockets and continued bone growth at a higher rate when compared to bioglass predicate¹
Excellent Handling Characteristics
Flowable NanoPutty is ideal to fill tight spaces, resist migration and won’t washout during irrigation.
INDICATIONS FOR USE/INTENDED USE
OsteoFlo is an osteoconductive synthetic bone graft indicated for use in orthopedic surgical sites to fill bony voids and gaps and to aid healing/ promote bone growth post-operation.
The graft is composed of HA, a-TCP, B-TCP, and bioactive glass. It is available in various graft quantities packaged in a syringe or a graft tube. The device has a composition that is moldable/flowable to allow it to be packed into bone voids with no mixing required.
All components are provided to the hospital sterilized and single use only.